You can configure Omega to check vendor pricing in real-time.  To get started, be sure you have enabled vendor ordering.  This article will guide you through enabling ordering.
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Once enabled, you can use cost plus pricing when setting up pricing profiles

Please note that if pricing is unavailable full list will be applied for quoting purposes. For this reason cost-plus pricing is not recommend for web quoter pricing.

In the advanced section, you can also configure a rule to check one vendor first, and then a different one next if no pricing information is available. To do so, enable Advanced Pricing Rules from within a Pricing Profile.

Next, select either "Markup Flat (Select Vendor Priority)" or "Markup Percentage (Select Vendor Priority)" from the rule dropdown.

Then, click the Select Vendor Priority button to configure both the amount of the markup (percentage or flat) and the order in which to prioritize vendors for pricing.